MUSC and Simens Healthineers

Joint Development Grant

MUSC-Siemens Ultrasound Pilot Project Grant Request for Applications (RFA)


RFA Release Date: December 7, 2020
Application Due: 5 PM EST, January 15, 2021
Earliest Anticipated Project Start Date: March 1st, 2021


This RFA solicits grant applications proposing novel, advanced, or enhanced uses of Siemens ultrasound technology. Co-sponsored by the MUSC Office of Innovation, Siemens Healthineers, and South Carolina Clinical and Translational Research (SCTR) Institute, this RFA provides one grant of up to $50,000 for a 12-month period in funding and access to Siemens technology, supporting an ultrasound-related pilot project designed to yield preliminary findings to expand clinical utility of a technology, support subsequent extramural grant applications, and/or result in joint product or service development. Clinical teams utilizing ultrasound technology are encouraged to apply. The aims specified by the application must be distinguishable from those funded by other grants.

While any potentially impactful Siemens ultrasound technology application proposal will be considered, specific priority areas include:

Siemens Healthineers ACUSON SC2000 PRIME Ultrasound System

  • Cardio-oncology: Velocity Vector Imaging (VVI) strain quantification (for oncology or another patient group) for early detection of cardiotoxicity
  • Interventional Guidance: Premarket collaboration “internal jugular access 4D intra-cardiac echocardiography (ICE) access for use in Trans-catheter Aortic Valve Replacement (TAVR) cases” feasibility (~15-20 patients)
  • Continuum of Care for Cardiac Valve Patients: Pre-procedural, procedural, and follow up for TAVR, Trans-catheter Mitral Valve Replacement (TMVR), and Right Heart studies
  • True Fusion: Structural Heart Disease (SHD) [Left Atrial Appendage Closure (LAAC), Paravalvular Leak (PVL)] studies to evaluate procedure time, fluoroscopy time, contrast usage, and outcomes

Siemens Sequoia

  • Radiology:
    • Post gross organ transplant evaluation
    • Chronic liver disease stiffness quantification
    • Bariatric imaging – pre/post op, follow-up
    • Deep Abdominal – Technically difficult exams
    • Focal liver lesion characterization [Contrast-Enhanced Ultrasound (CEUS)]

  • Vascular:
    • Deep/superficial venous disease (focus on technically difficult exams)
    • Atherosclerosis (pre-post intervention)
    • Abdominal vasculature (focus on technically difficult exams)

  • Pediatrics:
    • Neonatal brain
    • Acute abdomen
    • Liver disease (stiffness qualification)
    • Sickle cell (Transcranial Doppler Imaging [TCI])
    • Vesicoureteral reflux (CEUS)


Applications will be reviewed by a panel including scientific/technical evaluators, members from an external review board comprising MUSC and Siemens representatives, and Office of Innovation leadership.

Applications will be assessed to determine the potential for a project to:

  • Expand the clinical utility of a Siemens ultrasound technology and improve patient care.
  • Produce data that can be the basis for a larger-scale study with a subsequent extramural grant application, e.g., National Institutes of Health.
  • Result in new, jointly developed innovations.

Additionally, work proposed in the application will be reviewed for:

  • Likely completion of the aims within one-year timeframe
  • Appropriateness of the proposed budget expenditures with respect to the development plan for the innovation
  • Measurable, meaningful milestones for quarterly reporting

Official RFA (PDF)


Dayan Ranwala, Ph.D., Associate Director, SCTR Pilot Project Program and Team Science Program,